GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9457247 | 1 | rs444988 | chr6:167389674 | RNASET2 | chr6:167343008-167412795:- | -0.45 | -7.53 | 2.89E-11 | Crohn's disease |
| THYM | cis | rs1451375 | 1 | rs4452748 | chr7:50625056 | FIGNL1 | chr7:50511834-50518088:- | 0.3 | 4.64 | 1.09E-5 | Malaria |
| THYM | cis | rs9902453 | 1 | rs4465649 | chr17:28394747 | EFCAB5 | chr17:28256874-28435469:+ | -0.31 | -4.25 | 5.04E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs9902453 | 1 | rs4465650 | chr17:28396721 | EFCAB5 | chr17:28256874-28435469:+ | 0.31 | 4.26 | 4.84E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs9473555 | 1 | rs4469291 | chr6:49440614 | CENPQ | chr6:49431096-49460820:+ | -0.24 | -4.28 | 4.54E-5 | Folate pathway vitamin levels |
| THYM | cis | rs9473555 | 1 | rs4469291 | chr6:49440614 | MUT | chr6:49398994-49431031:- | 0.28 | 4.39 | 2.9E-5 | Folate pathway vitamin levels |
| THYM | cis | rs9457247 | 1 | rs448060 | chr6:167382622 | RNASET2 | chr6:167343008-167412795:- | -0.47 | -7.83 | 7.0E-12 | Crohn's disease |
| THYM | cis | rs9876781 | 1 | rs4490383 | chr3:48484683 | TREX1 | chr3:48501186-48509043:+ | -0.29 | -4.28 | 4.47E-5 | Longevity |
| THYM | cis | rs60843830 | 1 | rs4497901 | chr2:239969 | SH3YL1 | chr2:218138-264810:- | -0.32 | -4.66 | 1.02E-5 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs10935120 | 1 | rs4498009 | chr3:134198008 | ANAPC13 | chr3:134196547-134204865:- | 0.58 | 7.97 | 3.55E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs4498009 | chr3:134198008 | CEP63 | chr3:134204575-134293852:+ | 0.4 | 5.69 | 1.38E-7 | Height |
| THYM | cis | rs2243480 | 1 | rs451396 | chr7:65484074 | CCT6P1 | chr7:65216092-65228661:+ | 0.65 | 5.41 | 4.64E-7 | Diabetic kidney disease |
| THYM | cis | rs9902453 | 1 | rs4533340 | chr17:28277951 | EFCAB5 | chr17:28256874-28435469:+ | 0.32 | 4.3 | 4.2E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs10935120 | 1 | rs4535272 | chr3:134299916 | ANAPC13 | chr3:134196547-134204865:- | -0.59 | -8.05 | 2.38E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs4535272 | chr3:134299916 | CEP63 | chr3:134204575-134293852:+ | -0.43 | -6.17 | 1.7E-8 | Height |